Individuals who take acid-reducing medicine could have a better danger of migraine and different extreme headache than individuals who don’t take these medicines, in accordance with a research printed within the April 24, 2024, on-line subject of Neurology®Scientific Apply, an official journal of the American Academy of Neurology. The acid-reducing medicine includeproton pump inhibitors similar to omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, similar to cimetidine and famotidine, and antacid dietary supplements.
The research doesn’t show that acid-reducing medicine trigger migraine; it solely reveals an affiliation.
Acid reflux disease is when abdomen acid flows into the esophagus, normally after a meal or when mendacity down. Individuals with acid reflux disease could expertise heartburn and ulcers. Individuals with frequent acid reflux disease could develop gastroesophageal reflux illness, or GERD, which might result in most cancers of the esophagus.
“Given the extensive utilization of acid-reducing medicine and these potential implications with migraine, these outcomes warrant additional investigation,” stated research writer Margaret Slavin, PhD, RDN, of the College of Maryland in School Park. “These medicine are sometimes thought-about to be overprescribed, and new analysis has proven different dangers tied to long-term use of proton pump inhibitors, similar to an elevated danger of dementia.”
For the research, researchers checked out knowledge on 11,818 individuals who supplied info on use of acid-reducing medicine and whether or not they had migraine or extreme headache up to now three months.
A complete of 25% of individuals taking proton pump inhibitors had migraine or extreme headache, in comparison with 19% of those that weren’t taking the medicine. A complete of 25% of these taking H2 blockers had extreme headache, in comparison with 20% of those that weren’t taking these medicine. And 22% of these taking antacid dietary supplements had extreme headache, in comparison with 20% of these not taking antacids.
When researchers adjusted for different components that might have an effect on the danger of migraine, similar to age, intercourse and use of caffeine and alcohol, they discovered that individuals taking proton pump inhibitors had been 70% extra more likely to have migraine than individuals not taking proton pump inhibitors. These taking H2 blockers had been 40% extra possible and people taking antacid dietary supplements had been 30% extra possible.
“It is vital to notice that many individuals do want acid-reducing medicines to handle acid reflux disease or different circumstances, and folks with migraine or extreme headache who’re taking these medicine or dietary supplements ought to speak with their docs about whether or not they need to proceed,” Slavin stated.
Slavin famous that the research appeared solely at pharmaceuticals. A number of the medicine grew to become out there for over-the-counter use at non-prescription power throughout the research interval, however use of those over-the-counter medicine was not included on this research.
Different research have proven that individuals with gastrointestinal circumstances could also be extra more likely to have migraine, however Slavin stated that relationship isn’t more likely to absolutely clarify the tie between acid-reducing medicine and migraine discovered within the research.
A limitation of the research is {that a} small variety of individuals had been taking the medicine, particularly the H2 blockers.
